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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12160 scientific papers returned from the database with the search filters currently being used below.
There are 12160 scientific papers returned from the database with the search filters currently being used below.
Ribosome slowdown triggers codon-mediated mRNA decay independently of ribosome quality control
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Citation:
EMBO J. 2022 Mar 1;41(5):e109256. doi: 10.15252/embj.2021109256. Epub 2022 Jan 18. PMID: 35040509; PMCID: PMC8886528 Epub:
Not Epub Abstract:
The control of mRNA stability plays a central role in regulating gene expression patterns. Recent studies have revealed that... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Mishima Y, Han P, Ishibashi K, Kimura S, Iwasaki S. Ribosome slowdown triggers codon-mediated mRNA decay independently of ribosome quality control. EMBO J. 2022 Mar 1;41(5):e109256. doi: 10.15252/embj.2021109256. Epub 2022 Jan 18. PMID: 35040509; PMCID: PMC8886528. |
The cyclic dinucleotide 2'3'-cGAMP induces a broad antibacterial and antiviral response in the sea anemone Nematostella vectensis
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Citation:
Proc Natl Acad Sci U S A. 2021 Dec 21;118(51):e2109022118. doi: 10.1073/pnas.2109022118. PMID: 34903650; PMCID: PMC8713801 Epub:
Not Epub Abstract:
In mammals, cyclic dinucleotides (CDNs) bind and activate STING to initiate an antiviral type I interferon response. CDNs and... Delivery Method:
microinjection Organism or Cell Type:
Nematostella vectensis (anemone) Citation Extract: Margolis SR, Dietzen PA, Hayes BM, Wilson SC, Remick BC, Chou S, Vance RE. The cyclic dinucleotide 2'3'-cGAMP induces a broad antibacterial and antiviral response in the sea anemone Nematostella vectensis. Proc Natl Acad Sci U S A. 2021 Dec 21;118(51):e2109022118. doi: 10.1073/pnas.2109022118. PMID: 34903650; PMCID: PMC8713801. |
Slit2 is necessary for optic axon organization in the zebrafish ventral midline
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Citation:
Cells Dev. 2021 Apr 10;166:203677. doi: 10.1016/j.cdev.2021.203677. Online ahead of print Epub:
Not Epub Abstract:
Slit-Robo signaling has been implicated in regulating several steps of retinal ganglion cell axon guidance, with a central role... Organism or Cell Type:
zebrafish Citation Extract: Davison C, Zolessi FR. Slit2 is necessary for optic axon organization in the zebrafish ventral midline. Cells Dev. 2021 Apr 10;166:203677. doi: 10.1016/j.cdev.2021.203677. Online ahead of print. |
Role of vertebrate GAGA associated factor (vGAF) in early development of zebrafish
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Citation:
Cells Dev. 2021 Apr 24;166:203682. doi: 10.1016/j.cdev.2021.203682. Online ahead of print Epub:
Not Epub Abstract:
Homeotic genes and their genomic organization show remarkable conservation across bilaterians. Consequently, the regulatory... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Matharu NK, Yadav S, Kumar M, Mishra RK. Role of vertebrate GAGA associated factor (vGAF) in early development of zebrafish. Cells Dev. 2021 Apr 24;166:203682. doi: 10.1016/j.cdev.2021.203682. Online ahead of print. |
Targeted SMN Exon Skipping: A Useful Control to Assess In Vitro and In Vivo Splice-Switching Studies
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Citation:
Biomedicines. 2021;9(5):552. doi:10.3390/biomedicines9050552 Epub:
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The literature surrounding the use of antisense oligonucleotides continues to grow, with new disease and mechanistic... Delivery Method:
cell bathing, subcutaneous and intraperitoneal (s.c. & i.p.) injection Organism or Cell Type:
cell culture: human fibroblasts, SH-SY5Y neuroblastoma, mdx myoblasts; mice Citation Extract: Flynn LL, Mitrpant C, Adams A, Pitout IL, Stirnweiss A, Fletcher S, Wilton SD. Targeted SMN Exon Skipping: A Useful Control to Assess In Vitro and In Vivo Splice-Switching Studies. Biomedicines. 2021;9(5):552. doi:10.3390/biomedicines9050552. |
Surrogate production of genome-edited sperm from a different subfamily by spermatogonial stem cell transplantation
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Citation:
Sci China Life Sci. 2022 May;65(5):969-987. doi: 10.1007/s11427-021-1989-9. Epub 2021 Sep 24. PMID: 34586576 Epub:
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The surrogate reproduction technique, such as inter-specific spermatogonial stem cells (SSCs) transplantation (SSCT), provides... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Zhang F, Hao Y, Li X, Li Y, Ye D, Zhang R, Wang X, He M, Wang H, Zhu Z, Sun Y
. Surrogate production of genome-edited sperm from a different subfamily by spermatogonial stem cell transplantation. Sci China Life Sci. 2022 May;65(5):969-987. doi: 10.1007/s11427-021-1989-9. Epub 2021 Sep 24. PMID: 34586576. |
Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development
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Citation:
Elife. 2021 Oct 13;10:e69288. doi: 10.7554/eLife.69288. PMID: 34643182; PMCID: PMC8555986 Epub:
Not Epub Abstract:
The gene regulatory networks that coordinate the development of the cardiac and pulmonary systems are essential for terrestrial... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis, Xenopus tropicalis Citation Extract: Rankin SA, Steimle JD, Yang XH, Rydeen AB, Agarwal K, Chaturvedi P, Ikegami K, Herriges MJ, Moskowitz IP, Zorn AM. Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development. Elife. 2021 Oct 13;10:e69288. doi: 10.7554/eLife.69288. PMID: 34643182; PMCID: PMC8555986. |
Cryo-EM structures of human GMPPA–GMPPB complex reveal how cells maintain GDP-mannose homeostasis
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Citation:
Nat Struct Mol Biol. 2021;28(5):1–12. doi:10.1038/s41594-021-00591-9 Epub:
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GDP-mannose (GDP-Man) is a key metabolite essential for protein glycosylation and glycophosphatidylinositol anchor synthesis,... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Zheng L, Liu Z, Wang Y, Yang F, Wang J, Huang W, Qin J, Tian M, Cai X, Liu X, Mo X, Gao N, Jia D. Cryo-EM structures of human GMPPA–GMPPB complex reveal how cells maintain GDP-mannose homeostasis. Nat Struct Mol Biol. 2021;28(5):1–12. doi:10.1038/s41594-021-00591-9. |
A prometastatic splicing program regulated by SNRPA1 interactions with structured RNA elements
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Citation:
Science. 2021;372(6543): doi:10.1126/science.abc7531 Epub:
Not Epub Abstract:
Aberrant alternative splicing is a hallmark of cancer, yet the underlying regulatory programs that control this process remain... Delivery Method:
Endo-Porter Organism or Cell Type:
Cell culture: HCC1806-LM2 , MDA-LM2 Citation Extract: Fish L, Khoroshkin M, Navickas A, Garcia K, Culbertson B, Hänisch B, Zhang S, Nguyen CB, Soto LM, Dermit M, Mardakheh FK, Molina H, Alarcón C, Najafabadi HS, Goodarzi H. A prometastatic splicing program regulated by SNRPA1 interactions with structured RNA elements. Science. 2021;372(6543): doi:10.1126/science.abc7531. |
Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis
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Citation:
Science. 2021;372(6543):716-21. doi:10.1126/science.aaz2740 Epub:
Not Epub Abstract:
Transcription and metabolism both influence cell function, but dedicated transcriptional control of metabolic pathways that... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Rossmann MP, Hoi K, Chan V, Abraham BJ, Yang S, Mullahoo J, Papanastasiou M, Wang Y, Elia I, Perlin JR, Hagedorn EJ, Hetzel S, Weigert R, Vyas S, Nag PP, Sullivan LB, Warren CR, Dorjsuren B, Greig EC, Adatto I, Cowan CA, Schreiber SL, Young RA, Meissner A, Haigis MC, Hekimi S, Carr SA, Zon LI. Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis. Science. 2021;372(6543):716-21. doi:10.1126/science.aaz2740. |