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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12162 scientific papers returned from the database with the search filters currently being used below.
There are 12162 scientific papers returned from the database with the search filters currently being used below.
Proapoptotic Bad Involved in Brain Development, When Severely Defected, Induces Dramatic Malformation in Zebrafish
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Citation:
Int J Mol Sci. 2021;22:4832. doi:10.3390/ijms22094832 Epub:
Not Epub Abstract:
The BH3-only molecule Bad regulates cell death via its differential protein phosphorylation, but very few studies address its... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Hung J-C, Wu J-L, Hong J-R. Proapoptotic Bad Involved in Brain Development, When Severely Defected, Induces Dramatic Malformation in Zebrafish. Int J Mol Sci. 2021;22:4832. doi:10.3390/ijms22094832. |
Guidance by followers ensures long-range coordination of cell migration through α-catenin mechanoperception
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Citation:
Dev Cell. 2022 Jun 20;57(12):1529-1544.e5. doi: 10.1016/j.devcel.2022.05.001. Epub 2022 May 24. PMID: 35613615 Epub:
Not Epub Abstract:
Morphogenesis, wound healing, and some cancer metastases depend upon the migration of cell collectives that need to be guided... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Boutillon A, Escot S, Elouin A, Jahn D, González-Tirado S, Starruß J, Brusch L, David NB. Guidance by followers ensures long-range coordination of cell migration through α-catenin mechanoperception. Dev Cell. 2022 Jun 20;57(12):1529-1544.e5. doi: 10.1016/j.devcel.2022.05.001. Epub 2022 May 24. PMID: 35613615. |
Kindlin2 regulates neural crest specification via integrin-independent regulation of the FGF signaling pathway
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Citation:
Development. 2021 Apr 28:dev.199441. doi: 10.1242/dev.199441. Online ahead of print Epub:
Yes Abstract:
The focal adhesion protein Kindlin2 is essential for integrin activation, a process that is fundamental to cell-extracellular... Organism or Cell Type:
Xenopus Citation Extract: Wang H, Wang C, Long Q, Zhang Y, Wang M, Liu J, Qi X, Cai D, Lu G, Sun J, Yao YG, Chan WY, Chan WY, Deng Y, Zhao H. Kindlin2 regulates neural crest specification via integrin-independent regulation of the FGF signaling pathway. Development. 2021 Apr 28:dev.199441. doi: 10.1242/dev.199441. Online ahead of print. |
A Novel SLC5A5 Variant Reveals the Crucial Role of Kinesin Light Chain 2 in Thyroid Hormonogenesis
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Citation:
J Clin Endocrinol Metab. 2021 Apr 29:dgab283. doi: 10.1210/clinem/dgab283. Online ahead of print Epub:
Yes Abstract:
Context: Iodide transport defect (ITD) (Online Mendelian Inheritance in Man #274400) is an uncommon cause of dyshormonogenic... Organism or Cell Type:
zebrafish Citation Extract: Martín M, Modenutti CP, Gil Rosas ML, Peyret V, Geysels RC, Bernal Barquero CE, Sobrero G, Muñoz L, Signorino M, Testa G, Miras MB, Masini-Repiso AM, Calcaterra NB, Coux G, Carrasco N, Martí MA, Nicola JP. A Novel SLC5A5 Variant Reveals the Crucial Role of Kinesin Light Chain 2 in Thyroid Hormonogenesis. J Clin Endocrinol Metab. 2021 Apr 29:dgab283. doi: 10.1210/clinem/dgab283. Online ahead of print. |
The lncRNA H19 alleviates muscular dystrophy by stabilizing dystrophin
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Citation:
Nat Cell Biol. 2020 Nov;22(11):1332-1345. doi: 10.1038/s41556-020-00595-5 Epub:
Not Epub Abstract:
Dystrophin proteomic regulation in muscular dystrophies (MDs) remains unclear. We report that a long noncoding RNA (lncRNA),... Delivery Method:
i.v. injection Organism or Cell Type:
mice Citation Extract: Zhang Y, Li Y, Hu Q, Xi Y, Xing Z, Zhang Z, Huang L, Wu J, Liang K, Nguyen TK, Egranov SD, Sun C, Zhao Z, Hawke DH, Li J, Sun D, Kim JJ, Zhang P, Cheng J, Farida A, Hung MC, Han L, Darabi R, Lin C, Yang L. The lncRNA H19 alleviates muscular dystrophy by stabilizing dystrophin. Nat Cell Biol. 2020 Nov;22(11):1332-1345. doi: 10.1038/s41556-020-00595-5. |
Wnt signaling and tbx16 form a bistable switch to commit bipotential progenitors to mesoderm
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Citation:
Development. 2015 Jul 15;142(14):2499-507. doi: 10.1242/dev.124024. Epub 2015 Jun 10 Epub:
Not Epub Abstract:
Anterior to posterior growth of the vertebrate body is fueled by a posteriorly located population of bipotential neuro-... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Bouldin CM, Manning AJ, Peng YH, Farr GH 3rd, Hung KL, Dong A, Kimelman D. Wnt signaling and tbx16 form a bistable switch to commit bipotential progenitors to mesoderm. Development. 2015 Jul 15;142(14):2499-507. doi: 10.1242/dev.124024. Epub 2015 Jun 10. |
Antisense oligonucleotide-based treatment of retinitis pigmentosa caused by USH2A exon 13 mutations
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Citation:
Mol Ther. 2021;29(8)2441-55. doi: 10.1016/j.ymthe.2021.04.024. Online ahead of print Epub:
Not Epub Abstract:
Mutations in USH2A are among the most common causes of syndromic and non-syndromic retinitis pigmentosa (RP). The two most... Link:
Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Dulla K, Slijkerman R, van Diepen HC, Albert S, Dona M, Beumer W, Turunen JJ, Chan HL, Schulkens IA, Vorthoren L, Besten CD, Buil L, Schmidt I, Miao J, Venselaar H, Zang J, Neuhauss SCF, Peters T, Broekman S, Pennings R, Kremer H, Platenburg G, Adamson P, de Vrieze E, van Wijk E. Antisense oligonucleotide-based treatment of retinitis pigmentosa caused by USH2A exon 13 mutations. Mol Ther. 2021;29(8)2441-55. doi: 10.1016/j.ymthe.2021.04.024. Online ahead of print. |
Pinhead antagonizes Admp to promote notochord formation
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Citation:
iScience. 2021 May 7;24(6):102520. doi: 10.1016/j.isci.2021.102520. PMID: 34142034; PMCID: PMC8188501 Epub:
Not Epub Abstract:
Dorsoventral patterning of a vertebrate embryo critically depends on the activity of Smad1 that mediates signaling by BMP... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Itoh K, Ossipova O, Sokol SY. Pinhead antagonizes Admp to promote notochord formation. iScience. 2021 May 7;24(6):102520. doi: 10.1016/j.isci.2021.102520. PMID: 34142034; PMCID: PMC8188501. |
Anisomycin induces hair cell death and blocks supporting cell proliferation in zebrafish lateral line neuromast
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Citation:
Comp Biochem Physiol C Toxicol Pharmacol. 2021 Apr 19:109053. doi: 10.1016/j.cbpc.2021.109053 Epub:
Yes Abstract:
Ototoxicity of drugs is an important inducement for hearing loss. Anisomycin is a candidate drug for parasite, cancer,... Organism or Cell Type:
zebrafish Citation Extract: Yuan X, Qin Y, Wang J, Fan C. Anisomycin induces hair cell death and blocks supporting cell proliferation in zebrafish lateral line neuromast. Comp Biochem Physiol C Toxicol Pharmacol. 2021 Apr 19:109053. doi: 10.1016/j.cbpc.2021.109053. |
RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways
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Citation:
Nat Commun. 2021 Apr 20;12(1):2335. doi:10.1038/s41467-021-22531-3 Epub:
Not Epub Abstract:
Current therapeutic options for treating colorectal cancer have little clinical efficacy and acquired resistance during... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
cell culture: CMT93 cells; human organoids Citation Extract: Gudiño V, Pohl SÖ, Billard CV, Cammareri P, Bolado A, Aitken S, Stevenson D, Hall AE, Agostino M, Cassidy J, Nixon C, von Kriegsheim A, Freile P, Popplewell L, Dickson G, Murphy L, Wheeler A, Dunlop M, Din F, Strathdee D, Sansom OJ, Myant KB. RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways. Nat Commun. 2021 Apr 20;12(1):2335. doi:10.1038/s41467-021-22531-3. |