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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12371 scientific papers returned from the database with the search filters currently being used below.

Mutations in STN1 cause Coats plus syndrome and are associated with genomic and telomere defects

Authors:
Simon AJ, Lev A, Zhang Y, Weiss B, Rylova A, Eyal E, Kol N, Bare O, Cesarkas K, Soudack M, Greenberg-Kushnir N, Rhodes M, Wiest DL, Schiby G, Barshack I, Katz S, Pras E, Poran H, Reznik-Wolf H, Ribakovsky E, Simon C, Hazou W, Sidi Y, Lahad A, Katzir H, Sagie S, Aqeilan HA, Glousker G, Amariglio N, Tzfati Y, Selig S, Rechavi G, Somech R
Citation:
J Exp Med. 2016;[Epub ahead of print] doi:10.1084/jem.20151618
Epub:
Yes
Abstract:
The analysis of individuals with telomere defects may shed light on the delicate interplay of factors controlling genome...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Simon AJ, Lev A, Zhang Y, Weiss B, Rylova A, Eyal E, Kol N, Bare O, Cesarkas K, Soudack M, Greenberg-Kushnir N, Rhodes M, Wiest DL, Schiby G, Barshack I, Katz S, Pras E, Poran H, Reznik-Wolf H, Ribakovsky E, Simon C, Hazou W, Sidi Y, Lahad A, Katzir H, Sagie S, Aqeilan HA, Glousker G, Amariglio N, Tzfati Y, Selig S, Rechavi G, Somech R. Mutations in STN1 cause Coats plus syndrome and are associated with genomic and telomere defects. J Exp Med. 2016;[Epub ahead of print] doi:10.1084/jem.20151618.

Developmental Apoptosis Mediates Entry and Positioning of Microglia in the Zebrafish Brain

Authors:
Casano AM, Albert M, Peri F
Citation:
Cell Rep. 2016;16;1–10. doi:10.1016/j.celrep.2016.06.033
Epub:
Not Epub
Abstract:
In the brain, neurons that fail to assemble into functional circuits are eliminated. Their clearance depends on microglia,...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Casano AM, Albert M, Peri F. Developmental Apoptosis Mediates Entry and Positioning of Microglia in the Zebrafish Brain. Cell Rep. 2016;16;1–10. doi:10.1016/j.celrep.2016.06.033.

ANKS3 is mutated in a family with autosomal recessive laterality defect

Authors:
Shamseldin HE, Yakulov TA, Hashem A, Walz G, Alkuraya FS
Citation:
Hum Genet. 2016 Jul 14. [Epub ahead of print]
Epub:
Yes
Abstract:
Laterality defects are heterogeneous groups of congenital malformations that arise from perturbed asymmetrical development of...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Shamseldin HE, Yakulov TA, Hashem A, Walz G, Alkuraya FS. ANKS3 is mutated in a family with autosomal recessive laterality defect. Hum Genet. 2016 Jul 14. [Epub ahead of print].

Rescue of neural crest derived phenotypes in a zebrafish CHARGE model by sox10 downregulation

Authors:
Asad Z, Pandey A, Babu A, Sun Y, Shevade K, Kapoor S, Ullah I, Ranjan S, Scaria V, Bajpai R, Sachidanandan C
Citation:
Hum Mol Genet. 2016 Jul 13. pii: ddw198. [Epub ahead of print]
Epub:
Yes
Abstract:
CHD7 mutations are implicated in a majority of cases of the congenital disorder, CHARGE syndrome. CHARGE, an autosomal dominant...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Asad Z, Pandey A, Babu A, Sun Y, Shevade K, Kapoor S, Ullah I, Ranjan S, Scaria V, Bajpai R, Sachidanandan C. Rescue of neural crest derived phenotypes in a zebrafish CHARGE model by sox10 downregulation. Hum Mol Genet. 2016 Jul 13. pii: ddw198. [Epub ahead of print].

Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification

Authors:
Reischauer S, Stone OA, Villasenor A, Chi N, Jin S-W, Martin M, Lee MT, Fukuda N, Marass M, Witty A, Fiddes I, Kuo T, Chung W-S, Salek S, Lerrigo R, Alsiö J, Luo S, Tworus D, Augustine SM, Mucenieks S, Nystedt B, Giraldez AJ, Schroth GP, Andersson O, Stainier DYR
Citation:
Nature. 2016;535:294-8. doi:10.1038/nature18614
Epub:
Not Epub
Abstract:
Vascular and haematopoietic cells organize into specialized tissues during early embryogenesis to supply essential nutrients to...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Reischauer S, Stone OA, Villasenor A, Chi N, Jin S-W, Martin M, Lee MT, Fukuda N, Marass M, Witty A, Fiddes I, Kuo T, Chung W-S, Salek S, Lerrigo R, Alsiö J, Luo S, Tworus D, Augustine SM, Mucenieks S, Nystedt B, Giraldez AJ, Schroth GP, Andersson O, Stainier DYR. Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification. Nature. 2016;535:294-8. doi:10.1038/nature18614.

BMP and retinoic acid regulate anterior–posterior patterning of the non-axial mesoderm across the dorsal–ventral axis

Authors:
Naylor RW, Skvarca LB, Thisse C, Thisse B, Hukriede NA, Davidson AJ
Citation:
Nat Comm. 2016;7:12197. doi:10.1038/ncomms12197
Epub:
Not Epub
Abstract:
Despite the fundamental importance of patterning along the dorsal–ventral (DV) and anterior–posterior (AP) axes during...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Naylor RW, Skvarca LB, Thisse C, Thisse B, Hukriede NA, Davidson AJ. BMP and retinoic acid regulate anterior–posterior patterning of the non-axial mesoderm across the dorsal–ventral axis. Nat Comm. 2016;7:12197. doi:10.1038/ncomms12197.

Germline replacement by blastula cell transplantation in the fish medaka

Authors:
Li M, Hong N, Xu H, Song J, Yunhan Hong Y
Citation:
Sci Rep. 2016;6:29658. doi:10.1038/srep29658
Epub:
Not Epub
Abstract:
Primordial germ cell (PGC) specification early in development establishes the germline for reproduction and reproductive...
Delivery Method:
microinjection
Organism or Cell Type:
Oryzias latipes (medaka)
Citation Extract:
Li M, Hong N, Xu H, Song J, Yunhan Hong Y. Germline replacement by blastula cell transplantation in the fish medaka. Sci Rep. 2016;6:29658. doi:10.1038/srep29658.

The Joubert Syndrome Protein Inpp5e Controls Ciliogenesis by Regulating Phosphoinositides at the Apical Membrane

Authors:
Xu W, Jin M, Hu R, Wang H, Zhang F, Yuan S, Cao Y
Citation:
J Am Soc Nephrol. 2016 Jul 8. pii: ASN.2015080906. [Epub ahead of print]
Epub:
Yes
Abstract:
Phosphoinositides, a family of phosphorylated derivatives of phosphatidylinositol (PtdIns), are tightly regulated both...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Xu W, Jin M, Hu R, Wang H, Zhang F, Yuan S, Cao Y. The Joubert Syndrome Protein Inpp5e Controls Ciliogenesis by Regulating Phosphoinositides at the Apical Membrane. J Am Soc Nephrol. 2016 Jul 8. pii: ASN.2015080906. [Epub ahead of print].

Optimization of Morpholino Antisense Oligonucleotides Targeting the Intronic Repressor Element1 in Spinal Muscular Atrophy

Authors:
Osman EY, Washington CW 3rd, Kaifer KA, Mazzasette C, Patitucci TN, Florea KM, Simon ME, Ko CP, Ebert AD, Lorson CL
Citation:
Mol Ther. 2016 Jul 12. doi: 10.1038/mt.2016.145. [Epub ahead of print]
Epub:
Yes
Abstract:
Loss of Survival Motor Neuron-1 (SMN1) causes Spinal Muscular Atrophy (SMA), a devastating neurodegenerative disease. SMN2 is a...
Delivery Method:
Endo-Porter (cultures), icv (mice)
Organism or Cell Type:
iPS-derived SMA motor neurons, mice
Citation Extract:
Osman EY, Washington CW 3rd, Kaifer KA, Mazzasette C, Patitucci TN, Florea KM, Simon ME, Ko CP, Ebert AD, Lorson CL. Optimization of Morpholino Antisense Oligonucleotides Targeting the Intronic Repressor Element1 in Spinal Muscular Atrophy. Mol Ther. 2016 Jul 12. doi: 10.1038/mt.2016.145. [Epub ahead of print].

Meta-analysis of rare and common exome chip variants identifies S1PR4 and other loci influencing blood cell traits

Authors:
Pankratz N, Schick UM, Zhou Y, Zhou W, Ahluwalia TS, Allende ML, Auer PL, Bork-Jensen J, Brody JA, Chen MH, Clavo V, Eicher JD, Grarup N, Hagedorn EJ, Hu B, Hunker K, Johnson AD, Leusink M, Lu Y, Lyytikäinen LP, Manichaikul A, Marioni RE, Nalls MA, Pazoki R, Smith AV, van Rooij FJ, Yang ML, Zhang X, Zhang Y, Asselbergs FW, Boerwinkle E, Borecki IB, Bottinger EP, Cushman M, de Bakker PI, Deary IJ, Dong L, Feitosa MF, Floyd JS, Franceschini N, Franco OH, Garcia ME, Grove ML, Gudnason V, Hansen T, Harris TB, Hofman A, Jackson RD, Jia J, Kähönen M, Launer LJ, Lehtimäki T, Liewald DC, Linneberg A, Liu Y, Loos RJ, <authors hidden: database constraint> Thuesen BH, Tracy RP, Uitterlinden AG, Wang J, Wang J, Dehghan A, Huo Y, Cupples LA, Wilson JG, Proia RL, Zon LI, O'Donnell CJ, Reiner AP, Ganesh SK
Citation:
Nat Genet. 2016 Jul 11. doi: 10.1038/ng.3607. [Epub ahead of print]
Epub:
Yes
Abstract:
Hematologic measures such as hematocrit and white blood cell (WBC) count are heritable and clinically relevant. We analyzed...
Organism or Cell Type:
zebrafish
Citation Extract:
Pankratz N, Schick UM, Zhou Y, Zhou W, Ahluwalia TS, Allende ML, Auer PL, Bork-Jensen J, Brody JA, Chen MH, Clavo V, Eicher JD, Grarup N, Hagedorn EJ, Hu B, Hunker K, Johnson AD, Leusink M, Lu Y, Lyytikäinen LP, Manichaikul A, Marioni RE, Nalls MA, Pazoki R, Smith AV, van Rooij FJ, Yang ML, Zhang X, Zhang Y, Asselbergs FW, Boerwinkle E, Borecki IB, Bottinger EP, Cushman M, de Bakker PI, Deary IJ, Dong L, Feitosa MF, Floyd JS, Franceschini N, Franco OH, Garcia ME, Grove ML, Gudnason V, Hansen T, Harris TB, Hofman A, Jackson RD, Jia J, Kähönen M, Launer LJ, Lehtimäki T, Liewald DC, Linneberg A, Liu Y, Loos RJ, <authors hidden: database constraint> Thuesen BH, Tracy RP, Uitterlinden AG, Wang J, Wang J, Dehghan A, Huo Y, Cupples LA, Wilson JG, Proia RL, Zon LI, O'Donnell CJ, Reiner AP, Ganesh SK. Meta-analysis of rare and common exome chip variants identifies S1PR4 and other loci influencing blood cell traits. Nat Genet. 2016 Jul 11. doi: 10.1038/ng.3607. [Epub ahead of print].

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