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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 9876 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

The RNA-binding protein XSeb4R regulates maternal Sox3 at the posttranscriptional level during maternal-zygotic transition in Xenopus

Authors:
Bentaya S, Ghogomu SM, Vanhomwegen J, Van Campenhout C, Thelie A, Dhainaut M, Bellefroid E, Souopgui J
Citation:
Dev Biol. 2012 Jan 11. [Epub ahead of print]
Abstract:
The maternal-zygotic transition (MZT) is an embryonic event that overlaps with and plays key roles in primary germ layer...
Delivery Method:
Microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Bentaya S, Ghogomu SM, Vanhomwegen J, Van Campenhout C, Thelie A, Dhainaut M, Bellefroid E, Souopgui J. The RNA-binding protein XSeb4R regulates maternal Sox3 at the posttranscriptional level during maternal-zygotic transition in Xenopus. Dev Biol. 2012 Jan 11. [Epub ahead of print].

The type I serine/threonine kinase receptor Alk8/Lost-a-fin is required for Bmp2b/7 signal transduction during dorsoventral patterning of the zebrafish embryo

Authors:
Bauer H, Lele Z, Rauch GJ, Geisler R, Hammerschmidt M
Citation:
Development 2001 128(6):849-858
Abstract:
Ventral specification of mesoderm and ectoderm depends on signaling by members of the bone morphogenetic protein (Bmp) family....
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bauer H, Lele Z, Rauch GJ, Geisler R, Hammerschmidt M. The type I serine/threonine kinase receptor Alk8/Lost-a-fin is required for Bmp2b/7 signal transduction during dorsoventral patterning of the zebrafish embryo. Development 2001 128(6):849-858.

The zebrafish neckless mutation reveals a requirement for raldh2 in mesodermal signals that pattern the hindbrain

Authors:
Begemann G, Schilling TF, Rauch GJ, Geisler R, Ingham PW
Citation:
Development. 2001 Aug;128(16):3081-94
Abstract:
We describe a new zebrafish mutation, neckless, and present evidence that it inactivates retinaldehyde dehydrogenase type 2, an...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Begemann G, Schilling TF, Rauch GJ, Geisler R, Ingham PW. The zebrafish neckless mutation reveals a requirement for raldh2 in mesodermal signals that pattern the hindbrain. Development. 2001 Aug;128(16):3081-94.

Therapeutic Potential of Splice-Switching Oligonucleotides

Authors:
Bauman J, Jearawiriyapaisarn N, Kole R
Citation:
Oligonucleotides. 2009 Jan 6. [Epub ahead of print]
Abstract:
Alternative splicing enables a single pre-messenger RNA transcript to yield multiple protein isoforms, making it a major...
Citation Extract:
Bauman J, Jearawiriyapaisarn N, Kole R. Therapeutic Potential of Splice-Switching Oligonucleotides. Oligonucleotides. 2009 Jan 6. [Epub ahead of print].

TIF1gamma controls erythroid cell fate by regulating transcription elongation

Authors:
Bai X, Kim J, Yang Z, Jurynec MJ, Akie TE, Lee J, LeBlanc J, Sessa A, Jiang H, DiBiase A, Zhou Y, Grunwald DJ, Lin S, Cantor AB, Orkin SH, Zon LI
Citation:
Cell. 2010 Jul 9;142(1):133-43
Abstract:
Recent genome-wide studies have demonstrated that pausing of RNA polymerase II (Pol II) occurred on many vertebrate genes. By...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bai X, Kim J, Yang Z, Jurynec MJ, Akie TE, Lee J, LeBlanc J, Sessa A, Jiang H, DiBiase A, Zhou Y, Grunwald DJ, Lin S, Cantor AB, Orkin SH, Zon LI. TIF1gamma controls erythroid cell fate by regulating transcription elongation. Cell. 2010 Jul 9;142(1):133-43.

Transdermal use of phosphorodiamidate morpholino oligomer AVI-4472 inhibits cytochrome P450 3A2 activity in male rats

Authors:
Arora V, Hannah TL, Iversen PL, Brand RM
Citation:
Pharm Res. 2002 Oct;19(10):1465-70
Abstract:
PURPOSE: To determine if dermal absorption of an antisense phosphorodiamidate Morpholino oligomers (PMO) can inhibit target...
Delivery Method:
transdermal
Organism or Cell Type:
Sprague Dawley rats & hairless CRL:SK1 mice
Citation Extract:
Arora V, Hannah TL, Iversen PL, Brand RM. Transdermal use of phosphorodiamidate morpholino oligomer AVI-4472 inhibits cytochrome P450 3A2 activity in male rats. Pharm Res. 2002 Oct;19(10):1465-70.

Triplex formation by morpholino oligodeoxyribonucleotides in the HER-2/neu promoter requires the pyrimidine motif

Authors:
Basye J, Trent JO, Gao D, Ebbinghaus SW
Citation:
Nucleic Acids Res 2001 Dec 1;29(23):4873-80
Abstract:
Triplex-forming oligonucleotides (TFOs) are good candidates to be used as site-specific DNA-binding agents. Two obstacles...
Delivery Method:
not applicable
Organism or Cell Type:
not applicable
Citation Extract:
Basye J, Trent JO, Gao D, Ebbinghaus SW. Triplex formation by morpholino oligodeoxyribonucleotides in the HER-2/neu promoter requires the pyrimidine motif. Nucleic Acids Res 2001 Dec 1;29(23):4873-80.

Two highly related regulatory subunits of PP2A exert opposite effects on TGF-beta/Activin/Nodal signalling

Authors:
Batut J, Schmierer B, Cao J, Raftery LA, Hill CS, Howell M
Citation:
Development. 2008 Sep;135(17):2927-37
Abstract:
We identify Balpha (PPP2R2A) and Bdelta (PPP2R2D), two highly related members of the B family of regulatory subunits of the...
Organism or Cell Type:
Xenopus
Citation Extract:
Batut J, Schmierer B, Cao J, Raftery LA, Hill CS, Howell M. Two highly related regulatory subunits of PP2A exert opposite effects on TGF-beta/Activin/Nodal signalling. Development. 2008 Sep;135(17):2927-37.

U1 snRNP determines mRNA length and regulates isoform expression

Authors:
Berg MG, Singh LN, Younis I, Liu Q, Pinto AM, Kaida D, Zhang Z, Cho S, Sherrill-Mix S, Wan L, Dreyfuss G
Citation:
Cell. 2012 Jul 6;150(1):53-64. doi: 10.1016/j.cell.2012.05.029
Abstract:
U1 snRNP (U1), in addition to its splicing role, protects pre-mRNAs from drastic premature termination by cleavage and...
Delivery Method:
Electroporation
Organism or Cell Type:
cell culture: HeLa, NIH/3T3, and S2 cells
Citation Extract:
Berg MG, Singh LN, Younis I, Liu Q, Pinto AM, Kaida D, Zhang Z, Cho S, Sherrill-Mix S, Wan L, Dreyfuss G. U1 snRNP determines mRNA length and regulates isoform expression. Cell. 2012 Jul 6;150(1):53-64. doi: 10.1016/j.cell.2012.05.029.

Williams Syndrome Transcription Factor is critical for neural crest cell function in Xenopus laevis

Authors:
Barnett C, Yazgan O, Kuo HC, Malakar S, Thomas T, Fitzgerald A, Harbour B, Henry JJ, Krebs JE
Citation:
Mech Dev. 2012 Jun 9. [Epub ahead of print]
Abstract:
Williams Syndrome Transcription Factor (WSTF) is one of ∼25 haplodeficient genes in patients with the complex developmental...
Delivery Method:
Microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Barnett C, Yazgan O, Kuo HC, Malakar S, Thomas T, Fitzgerald A, Harbour B, Henry JJ, Krebs JE. Williams Syndrome Transcription Factor is critical for neural crest cell function in Xenopus laevis. Mech Dev. 2012 Jun 9. [Epub ahead of print].

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